Lisa Barons Pensabene, head of the Firm’s Life Science Litigation practice, handles high stakes patent litigation in the pharmaceutical and chemical industries. A first chair trial lawyer, she has led major pharmaceutical and chemical patent litigations in bench and jury trials, and arguments on appeal. She specializes in pharmaceutical patent litigation with her experience spanning treatment of cancers, HIV, immunological disorders, diabetes, cardiovascular disease, neurological disorders, ophthalmic disorders and pain. Lisa also is well-known as an expert on litigation on biologics, including biosimilars. Lisa is well-versed in post grant review procedures in the Patent Office, particularly inter partes review procedures. Lisa is committed to diversity in the profession and is one of the co-founders of WIN: Women in IP Network.
The recipient of numerous accolades, Lisa remains most proud of clients’ continuing trust in the work of her team. Lisa was named a BTI Client Service All Star (2021, 2022), Hatch-Waxman Litigator of the Year - Branded by LMG Life Sciences (2020) and a “Life Science Star.” She was named to Managing Intellectual Property’s global list of the “Top 250 Women in IP” (2018-2022). In her repeated recognition as a leading attorney in IAM Patent 1000, clients say: “Tenacious, tireless and thorough, Lisa is always someone you can trust.” IAM reports clients call Lisa “smart and strategic,” praise her ability to “master very complex science and explain it to a lay audience” and “take apart opposing experts on cross-examination with ease.” They recount that “Lisa is a great writer and a terrific advocate in court, and a true pleasure to deal with.” She repeatedly has been listed in IAM 250: The World’s Leading Patent Litigators. She is recognized by Legal 500 which notes that she heads O’Melveny’s life sciences practice. Chambers notes that she is a “key partner” in the New York office.
- Lead counsel for international pharmaceutical company on patents related to treatment of irritable bowel syndrome.
- Lead counsel for international pharmaceutical company on patents related to treatment of hypotrichosis.
- Lead trial counsel for international pharmaceutical company against multiple generic challengers on patents related to treatment of HIV.
- Lead counsel for international pharmaceutical company in BPCIA litigation.
- Lead counsel for international pharmaceutical company in negotiations on phage display technology.
- Lead trial counsel for international pharmaceutical company against multiple generic challengers on patents related to injectable multiple myeloma treatment.
- Lead counsel in inter partes review relating to breast cancer treatment.
- Lead trial counsel for international pharmaceutical company against multiple generic challengers on patents related to breast cancer treatment.
- Lead trial counsel for international pharmaceutical company against generic company on patents related to treatment for ophthalmic inflammation in district court litigation and representing company in inter partes review.
- Lead counsel for international biotechnology trade organization in amicus briefing in the Federal Circuit.
- Lead counsel for international biotechnology company on issues of biosimilars and inter partes review.
- Lead trial counsel for international pharmaceutical companies against generic companies on patents related to anti-platelet treatment.
- Lead trial counsel for international pharmaceutical company against biotechnology company on patents related to recombinant antibodies.
- Patent counsel for international pharmaceutical company in antitrust action relating to enforcement of patents on syringes.
- Co-lead trial counsel for international pharmaceutical company against generic company on numerous patents covering an ophthalmic antibiotic preparation.
- Lead trial counsel for international pharmaceutical company against generic companies on a patent covering an immunosuppressant drug.
- Lead trial counsel for biotechnology company against the Patent Office in district court action on patent term extension.
- Lead trial counsel for international pharmaceutical company against generic company on a patent on an angiotensin receptor blocker used as an active ingredient in high blood pressure medicines.
- Represented international pharmaceutical company against generic company on a patent relating to a herpes treatment.
- Lead trial counsel for international pharmaceutical company against generic companies on a patent covering a treatment for symptoms of Sjogren's Syndrome.
- Represented international pharmaceutical company against generic companies on a patent covering a treatment for psychotic disorders.
- Lead trial counsel for international pharmaceutical company against generic companies on a patent for the formulation of a beta blocker treatment for high blood pressure and angina pectoris.
- Lead trial counsel for international pharmaceutical company against generic companies in a multi-district litigation on patents covering a calcium channel blocking treatment for high blood pressure.
- Represented international pharmaceutical company against another international pharmaceutical company on a patent for a treatment to prevent diabetes.
- Represented international pharmaceutical company against generic companies on a patent for a nasally administered pain medication.
- Represented international chemical company against international chemical company on a patent relating to a tire yarns.
- Represented international chemical company against international chemical company on a patent relating to magnetic recording tape.
Admissions
Bar Admissions
- New York
Court Admissions
- US District Court for the District of Delaware
Education
- Georgetown University, J.D., 1991: magna cum laude, Order of the Coif
- Pennsylvania State University, B.S., Biology, 1986
Honors & Awards
- Recognized by Best Lawyers in America for Biotechnology and Life Sciences Practice, Litigation - Intellectual Property, and Corporate Governance Law in New York, NY (2024-2025)
- Named a “National Practice Area Star” and “Litigation Star” in Intellectual Property by Benchmark Litigation (2021-2025)
- Recognized by Chambers USA for Intellectual Property: Patent (2023-2024)
- Consecutively recommended by The Legal 500 US each year since 2016, including for Patents: Litigation (Full Coverage) and Healthcare: Life Sciences
- Named Hatch-Waxman Litigator of the Year - Branded by LMG Life Sciences (2020), and repeatedly shortlisted for the award (2015-2019, 2022-2024)
- Named a “Life Science Star” for Hatch-Waxman Patent Litigation, Patent Strategy & Management, General Patent Litigation by LMG Life Sciences (2015-2020, 2022-2023)
- Listed among “The World’s Leading Patent Litigators,” IAM 250
- Repeatedly recognized as a leading attorney in IAM Patent 1000
- Included in the 2023 edition of the IAM Global Leaders Guide
- Recognized by Managing Intellectual Property's “Top 250 Women in IP” global list (2018-2023)
- Named a “National Patent Star” by Managing Intellectual Property (2023)
- Named to Managing Intellectual Property's “IP Stars” list (2018-2020)
- Named a "National Top 30 Life Sciences Practitioner in the US" in Euromoney's Best of the Best USA Expert Guide (2021)
- Recognized in Euromoney's "Best of the Best USA Expert Guide" (multiple years)
- Shortlisted, Best Woman in Patent Law, Euromoney (2014)
- Recognized in Euromoney’s “Women in Business Law Expert Guides” (2013)
- Named a “Client Service All-Star” by The BTI Consulting Group (2021, 2022)
- Selected to “Super Lawyers” list for Intellectual Property Litigation in New York (multiple years including 2023)
Professional Activities
Co-founder
- WIN: Women in Intellectual Property Network
Member
- American Bar Association
Author
- “AI and Life Sciences Patents: Separating Myth From Reality,” New York Law Journal (March 2020)
Featured
- Leading by Example: Elevating Women through Intentionality, ABA Landslide (December 2019)
Speaker
- Panelist, "General Counsel Roundtable," Pro Bono Institute (October 26, 2021)